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Science 17 January 1964:
Vol. 143. no. 3603, pp. 250 - 251
DOI: 10.1126/science.143.3603.250
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Articles

Precipitins in the Rabbit Produced by Protein Polysaccharide from Bovine Nasal Cartilage

Nicola Di Ferrante 1

1 Department of Physiology, University of Cincinnati College of Medicine, Cincinnati 19, Ohio

Precipitins have been produced in the rabbit by injecting protein polysaccharide from bovine nasal cartilage in Freund's adjuvant. These antibodies did not precipitate either protein polysaccharides extracted from other species, or the separated protein and carbohydrate moieties of the antigen. It is postulated that the antibodies are directed toward determinants consisting of carbohydrate and amino acid residues linked in three-dimensional arrangements specific for different protein polysaccharides.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Synovial Cell Synthesis of a Substance Immunologically Like Cartilage Proteinpolysaccharide.
R. Janis, J. Sandson, C. Smith, and D. Hamerman (1967)
Science 158, 1464-1467
   Abstract »    PDF »
Protein- Polysaccharide Loss during Endochondral Ossification: Immunochemical Evidence.
A. Hirschman and D. D. Dziewiatkowski (1966)
Science 154, 393-395
   Abstract »    PDF »
Cellular Origin of Hyaluronateprotein in the Human Synovial Membrane.
S. Blau, R. Janis, D. Hamerman, and J. Sandson (1965)
Science 150, 353-355
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)