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Science 10 January 1964:
Vol. 143. no. 3602, pp. 133 - 134
DOI: 10.1126/science.143.3602.133
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Articles

Ethacrynic Acid: Diuretic Property Coupled to Reaction with Sulfhydryl Groups of Renal Cells

Robert M. Komorn 1 and Edward J. Cafruny 1

1 Department of Pharmacology, University of Michigan Medical School, Ann Arbor

Ethacrynic acid, injected intravenously after surgical removal of one kidney of anesthetized dogs, lowered the concentration of protein-bound sulfhydryl groups in cells of the remaining kidney. Chloride excretion and urinary output of the kidney exposed to the drug increased. These findings indicate that the diuresis produced by ethacrynic acid may be related to its capacity for binding sulfhydryl groups of renal cellular proteins.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Clinical Experience With Intravenous Administration of Ethacrynic Acid.
G. V. Irons Jr., Y.-H. Kong, W. M. Ginn Jr., and E. S. Orgain (1965)
JAMA 194, 1348-1351
   Abstract »    PDF »
Ethacrynic Acid in Pathological Fluid Retention.
R. J. Sperber, L. B. Di Re, M. M. Singer, S. Fisch, and A. C. DeGraff (1965)
JAMA 191, 703-706
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)