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Science 13 December 1963:
Vol. 142. no. 3598, pp. 1473 - 1474
DOI: 10.1126/science.142.3598.1473
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Articles

Inhibition of Growth of Chick Embryo by Inhibition of Deoxycytidylate Deaminase

Jay S. Roth 1, G. Buccino 1, and N. W. Klein 1

1 Institute of Cellular Biology, University of Connecticut, Storrs

Deoxyguanylate when added to chick embryos grown in explant inhibited growth and development. Deoxycytidylate deaminase activity was inhibited both in the explants and in vitro; since the effect was quite specific, it is suggested that this may represent another control mechanism for deoxynucleotide synthesis.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)