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Science 13 December 1963:
Vol. 142. no. 3598, pp. 1458 - 1463
DOI: 10.1126/science.142.3598.1458
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Articles

Tautomerism and Protonation of Guanosine

H. Todd Miles 1, Frank B. Howard 1, and Joe Frazier 1

1 Laboratory of Molecular Biology, National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland

Guanosine has been demonstrated, by infrared and nuclear magnetic resonance spectroscopy, to have a keto-amino structure in neutral aqueous solution and to undergo protonation at N7 in acid solution.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)