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Science 22 November 1963:
Vol. 142. no. 3595, pp. 1083 - 1085
DOI: 10.1126/science.142.3595.1083
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Articles

Rationale for a Universal Genetic Code

Ralph T. Hinegardner 1 and Joseph Engelberg 2

1 Department of Zoology, Columbia University, New York
2 Department of Physiology and Biophysics, University of Kentucky Medical College, Lexington

A mutation in the genetic code would place new amino acids in certain loci and entirely eliminate amino acids from other loci of practically all proteins in an organism. It is reasonable to postulate that mutations of this kind cannot supplant the original code. The genetic code, once established, would therefore remain invariant.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Fine Structure of RNA Codewords Recognized by Bacterial, Amphibian, and Mammalian Transfer RNA.
R. E. Marshall, C. T. Caskey, and M. Nirenberg (1967)
Science 155, 820-826
   Abstract »    PDF »
Universality in the Genetic Code.
C. R. Woese, R. T. Hinegardner, and J. Engelberg (1964)
Science 144, 1030-1031
   PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)