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Science 18 October 1963:
Vol. 142. no. 3590, pp. 394 - 396
DOI: 10.1126/science.142.3590.394
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Articles

Norepinephrine and 3,4-Dihydroxy-Phenethylamine Turnover in Guinea Pig Brain in vivo

S. Udenfriend 1 and P. Zaltzman-Nirenberg 1

1 National Heart Institute, National Institutes of Health, Bethesda 14, Maryland

By administering C14-la-beled tyrosine or H3-labeled 3,4-dihy-droxyphenylalanine to guinea pigs it has been possible to achieve sufficient labeling of the norepinephrine and dopamine in the brain to permit measurement of their turnover rates. The half-life of brain dopamine was about 2.5 hours. The half-life of norepinephrine was about 4 hours, suggesting a rate of synthesis of at least 0.03 to 0.04, µg/g per hr or 2.4 µg/day for the whole guinea pig brain.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Circulating Beta Adrenergic Stimulator During Elevated Cerebrospinal Fluid Pressure.
R. E. Brashear and J. C. Ross (1971)
Arch Intern Med 127, 748-753
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Decrease in Adrenal Tyrosine Hydroxylase and Increase in Norepinephrine Synthesis in Rats Given L-Dopa.
W. Dairman and S. Udenfriend (1971)
Science 171, 1022-1024
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