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Science 18 October 1963:
Vol. 142. no. 3590, pp. 393 - 394
DOI: 10.1126/science.142.3590.393
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Articles

Polypeptide Chains of Rabbit Gamma Globulin

Parker A. Small Jr. 1, Joan E. Kehn 1, and Michael E. Lamm 1

1 National Institute of Mental Health, Bethesda 14, Maryland

Rabbit gamma globulin has been extensively reduced, and its polypeptide chains separated by gel filtration on Sephadex G-200 in SM guanidine hydrochloride. The larger H (or A) chains make up two-thirds of the molecule and have a molecular weight of approximately 55,000 each. The smaller L (or B) chains account for the other one-third and have a molecular weight of approximately 25,000 each. The data are consistent with a model of the gamma globulin molecule that has two H and two L chains.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Polypeptide Chaini of Immunoglobulins from the Smooth Dogfish (Mustelus canis).
J. Marchalonis and G. M. Edelman (1966)
Science 154, 1567-1568
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