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Science 11 October 1963:
Vol. 142. no. 3589, pp. 237 - 239
DOI: 10.1126/science.142.3589.237
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Articles

Freezing-Point Depression: New Method for Measuring Ultramicro Quantities of Fluids

Denis J. Prager 1 and Robert L. Bowman 1

1 Laboratory of Technical Development, National Heart Institute, Bethesda 14, Maryland

Accurate determination of the solute content of millimicroliter samples of biological fluids can conveniently be made with an instrument consisting of a thermoelectric cooler controlled by an electronic proportional servo system. Accuracies to within less than 2 percent have been achieved in determining the osmolarity of body fluids.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)