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Science 17 May 1963:
Vol. 140. no. 3568, pp. 803 - 805
DOI: 10.1126/science.140.3568.803
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Articles

Vitamin E Oxidation with Alkaline Ferricyanide

W. A. Skinner 1 and P. Alaupovic 2

1 Department of Pharmaceutical Chemistry, Stanford Research Institute, Menlo Park, California
2 Cardiovascular Section, Oklahoma Medical Research Institute, and Department of Biochemistry, University of Oklahoma School of Medicine, Oklahoma City

Oxidation of dl-agr-tocopherol or its model, 6-hydroxy-2,2,5,7,8-pentamethylchroman, with alkaline ferricyanide yields a variety of products. In addition to the known dimeric keto ether, two new products, compound A, a trimer, and compound B, an isomer of compound A, were ioslated. Ultraviolet and infrared absorption spectra and paper chromatography indicate that compound A might be identical with liver metabolite "O" which results from the addition of agr-tocopherol to the diet.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)