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Science 19 April 1963:
Vol. 140. no. 3564, pp. 314 - 316
DOI: 10.1126/science.140.3564.314
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Articles

Reticulocyte Protein Synthesis: Response of Ribosome Fractions to Polyuridylic Acid

I. Bernard Weinstein 1, Alan N. Schechter 1, Edward R. Burka 1, and Paul A. Marks 1

1 Department of Medicine, Columbia University College of Physicians and Surgeons, New York 32

Reticulocyte ribosomes with sedimentation coefficients greater than 100S ("heavy" ribosomes) appear to be considerably more active in hemoglobin synthesis than are 78S ribosomes. When assayed for the ability to synthesize polyphenylalanine in the presence of polyuridylic acid, the 78S ribosomes and "heavy" ribosomes have similar activities. Polyuridylic acid inhibits incorporation by "heavy" ribosomes of amino acids other than phenylalanine.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)