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Science 19 April 1963:
Vol. 140. no. 3564, pp. 300 - 301
DOI: 10.1126/science.140.3564.300
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Articles

Acetylcholine and Cholinacetylase Content of Synaptic Vesicles

E. de Robertis 1, L. Salganicoff 1, L. M. Zieher 1, and Georgina Rodriguez de Lores Arnaiz 1

1 Instituto de Anatomía General y Embriología, Facultad de Ciencias Médicas, Buenos Aires, Argentina

Acetylcholine, cholinacetylase, and acetylcholinesterase were determined in three subfractions that resulted from the osmotic shock of the "mitochondrial" fraction of the rat brain. Acetylcholine and cholinacetylase were found concentrated in the subfraction that contained mainly synaptic vesicles and some membranes, whereas the larger proportion of the acetylcholinesterase was observed in the subfraction that contained torn nerve endings. These results support the idea that synaptic vesicles are the morphological units of acetylcholine within the synapse.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)