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Science 26 October 1962:
Vol. 138. no. 3539, pp. 518 - 519
DOI: 10.1126/science.138.3539.518
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Articles

Sarcoma 180 Inhibition by Combinations of 6-Thioguanine and Uracil Mustard

Barbara A. Booth 1 and Alan C. Sartorelli 1

1 Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut

Combinations of 6-thioguanine and uracil mustard produced greater inhibition of the growth of sarcoma 180 than that equivalent to the sum of the inhibitory effects caused by the optimum levels of the individual drugs. This potentiation was accomplished without marked weight loss by the host. Some possible biochemical mechanisms responsible for the drug synergy are discussed.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)