Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 19 October 1962:
Vol. 138. no. 3538, pp. 439 - 440
DOI: 10.1126/science.138.3538.439
Prev | Table of Contents | Next

Articles

Ethynodiol Diacetate as a New, Highly Potent Oral Inhibitor of Ovulation

Gregory Pincus 1, Celso R. Garcia 1, Manuel Paniagua 1, and John Shepard 1

1 Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts, and Family Planning Association of Puerto Rico, Rio Piedras

Ethynodiol (17agr-ethinyl-4- estrene-3,17-diol) diacetate, a potent progestin and oral inhibitor of ovulation in the rabbit, gives evidence of possessing antiovulatory activity when it is administered orally to women. When it is combined with an estrogen it provides adequate control of menstrual cyclicity, and, thus far, complete contraceptive effectiveness even in low daily doses.

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)