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Science 8 June 1962:
Vol. 136. no. 3519, pp. 879 - 880
DOI: 10.1126/science.136.3519.879
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Articles

Urinary Excretion of Amines in Phenylketonuria and Mongolism

Thomas L. Perry 1

1 Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, and Pacific State Hospital, Pomona, California

Children with phenylketonuria excrete considerably less serotonin and tryptamine and somewhat less normetanephrine and p-tyramine than normal children. The excretion of these amines was not decreased in mongolism. Even during monoamine oxidase blockade, o-tyramine could not be detected in the urine of phenylketonurics. These findings are discussed in relation to the mental defect of phenylketonuria.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
5-Hydroxytryptophan Administration in Phenylketonuria.
T. L. PERRY and B. TISCHLER (1964)
Arch Pediatr Adolesc Med 107, 586-589
   Abstract »    PDF »
Pediatric Progress: Phenylketonuria in Pediatric Practice.
J. W. Farquhar, J. Richmond, and H. P. Tait (1963)
Clinical Pediatrics 2, 504-516
   PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)