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Science 27 April 1962:
Vol. 136. no. 3513, pp. 315 - 316
DOI: 10.1126/science.136.3513.315
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Articles

Actinomycin D Inhibition of Deoxyribonucleic Acid-Dependent Synthesis of Ribonucleic Acid

I. H. Goldberg 1 and M. Rabinowitz 1

1 Departments of Medicine and Biochemistry and Argonne Cancer Research Hospital, University of Chicago, Chicago, Illinois

Minute amounts of actinomycin D inhibit the synthesis of ribonucleic acid by nuclear extracts of HeLa cells in a ribonucleic acid-synthesizing system that is dependent on deoxyribonucleic acid and requires the presence of all four ribonucleoside triphosphates. The inhibition can be reversed by adding deoxyribonucleic acid to the enzymatic reaction. These findings support the work of others on the mode of action of actinomycin D in vivo.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Are the Effects of T3 on Resting Metabolic Rate in Euthyroid Rats Entirely Caused by T3 Itself?.
M. Moreno, A. Lombardi, L. Beneduce, E. Silvestri, G. Pinna, F. Goglia, and A. Lanni (2002)
Endocrinology 143, 504-510
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Effect of Dactinomycin on Pathogenic Fungi: With Special Reference to Experimental Cryptococcosis.
F. REISS and G. SZILAGYI (1967)
Arch Dermatol 95, 124-130
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Base Specificity in the Interaction of Polynucleotides with Antibiotic Drugs.
D. C. Ward, E. Reich, and I. H. Goldberg (1965)
Science 149, 1259-1263
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Actinomycin D: An Effect on Rat Liver Homogenates Unrelated to Its Action on RNA Synthesis.
M. Revel, H. H. Hiatt, and J.-P. Revel (1964)
Science 146, 1311-1313
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Insulin Action in Alloxan Diabetes Modified by Actinomycin D.
A. Gellhorn and W. Benjamin (1964)
Science 146, 1166-1168
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Antibody Formation in vitro by Separated Spleen Cells: Inhibition by Actinomycin or Chloramphenicol.
S.-E. Svehag (1964)
Science 146, 659-661
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Actinomycin Resistance in Bacillus subtilis.
I. J. Slotnick and B. H. Sells (1964)
Science 146, 407-408
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Intestinal Phosphatase Activity: Acceleration of Increase by Puromycin and Actinomycin.
F. Moog (1964)
Science 144, 414-416
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Actinomycin D: Suppression of Recovery in X-Irradiated Mammalian Cells.
M. M. Elkind, G. F. Whitmore, and T. Alescio (1964)
Science 143, 1454-1457
   Abstract »    PDF »
Actinomycin: Correlation of Structure and Function of Its Complexes with Purines and DNA.
E. Reich (1964)
Science 143, 684-689
   Abstract »    PDF »
Breakdown of Rat-Liver Ergosomes in vivo after Actinomycin Inhibition of Messenger RNA Synthesis.
T. Staehelin, F. O. Wettstein, and H. Noll (1963)
Science 140, 180-183
   Abstract »    PDF »
Patterns of Macromolecular Synthesis in Normal and Virus-infected Mammalian Cells.
R. M. Franklin and D. Baltimore (1962)
Cold Spring Harb Symp Quant Biol 27, 175-198
   Abstract »    PDF »


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