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Science 16 December 1960:
Vol. 132. no. 3442, pp. 1840 - 1841
DOI: 10.1126/science.132.3442.1840
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Articles

Photodynamic Inactivation of Infectious Nucleic Acid

M. Chessin 1

1 Department of Botany, Montana State University, Missoula

Tobacco mosaic virus-infectious nucleic acid causes a color shift when combined with acridine orange, methylene blue, and safranine. A high concentration of acridine orange inactivates infectious nucleic acid even in darkness, while a mixture of nucleic acid with a low concentration of the dye must be exposed to visible light prior to inoculation for inactivation to occur.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)