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Science 29 July 1960:
Vol. 132. no. 3422, pp. 298 - 299
DOI: 10.1126/science.132.3422.298
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Articles

Allelic Genes in the Housefly Producing Modified Enzymes That Cause Organophosphate Resistance

F. J. Oppenoorth 1 and K. van Asperen 1

1 Laboratorium voor Insekticidenonderzoek, Utrecht, Netherlands

In all of six phosphate-resistant strains of Musca domestica L. a mutant gene is present which produces an altered ali-esterase. The modified enzymes are no longer irreversibly inhibited by the oxygen analogs of the insecticides to which the strains are resistant but can slowly convert them. In five of the strains the resistance is caused by this gene only.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A single amino acid substitution converts a carboxylesterase to an organophosphorus hydrolase and confers insecticide resistance on a blowfly.
R. D. Newcomb, P. M. Campbell, D. L. Ollis, E. Cheah, R. J. Russell, and J. G. Oakeshott (1997)
PNAS 94, 7464-7468
   Abstract »    Full Text »    PDF »
Induction of Microsomal Oxidase in F1 Hybrids of a High and a Low Oxidase Housefly Strain.
L. C. Terriere, S. J. Yu, and R. F. Hoyer (1971)
Science 171, 581-583
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)