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Science 8 July 1960:
Vol. 132. no. 3419, pp. 87 - 89
DOI: 10.1126/science.132.3419.87
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Articles

Electronic Structure and Nicotine-like Stimulant Activity in Choline Phenyl Ethers

Kenichi Fukui 1, Chikayoshi Nagata 1, and Akira Imamura 1

1 Faculty of Engineering, Kyoto University, Kyoto, Japan

Frontier electron density at the ether oxygen position and superdelocalizability at the ortho position show good parallelism with biological activity—that is, the stimulant activity of phenyl ether choline molecules. The mechanism of the biological action is discussed in connection with this finding.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)