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Science 13 May 1960:
Vol. 131. no. 3411, p. 1449
DOI: 10.1126/science.131.3411.1449
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Articles

Induced Phenotypic Resistance to an Antimetabolite

H. S. Moyed 1

1 Department of Bacteriology and Immuinology, Harvard Medical School, Boston, Massachusetts

Resistance to bacteriostasis by 2-thiazole alanine develops rapidly; however, such resistance is lost during growth in the absence of the analog. This induced resistance is accompanied by increased formation of an enzyme sensitive to 2-thiazole alanine. Maintenance of the elevated enzyme levels in growing cells, like resistance, requires the presence of the analog.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Interference with Feedback Control of Enzyme Activity.
H. S. Moyed (1961)
Cold Spring Harb Symp Quant Biol 26, 323-329
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Science. ISSN 0036-8075 (print), 1095-9203 (online)