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Science 6 May 1960:
Vol. 131. no. 3410, pp. 1372 - 1374
DOI: 10.1126/science.131.3410.1372
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Articles

Technique for the Study of Alternate Metabolic Pathways; Epinephrine Metabolism in Man

Irwin J. Kopin 1

1 Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland

A general method of determining the relative magnitudes of different pathways of formation of a urinary metabolite from a single precursor substance is described. The method requires the administration of the precursor and an intermediate labeled with different isotopes, and the determination of the ratio of the isotopes in the metabolites. A preliminary application to epinephrine metabolism in man is presented.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)