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Science 8 April 1960:
Vol. 131. no. 3406, pp. 1041 - 1043
DOI: 10.1126/science.131.3406.1041
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Articles

Influence of pH on the Toxicity of Nitrogen Mustard

Laurens P. White 1

1 Children's Cancer Research Foundation and Department of Pathology, Children's Hospital, Boston, Mass.

The experiments reported here demonstrate the unexpected finding that, in mice, the pH of nitrogen mustard solution at the time it is injected into the animal appears to determine the toxicity of the material. At certain doses, highly acid solutions of nitrogen mustard show no toxic effects, while alkaline solutions at the same dose are invariably lethal. From further experiments on the antitumor activity of acid solutions of nitrogen mustard, it is cojpcluded that the toxic effect is separable from the antitumor effect.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Nitrogen Mustard: Diminution of Toxicity in Axenic Mice.
L. P. White and E. F. Claflin (1963)
Science 140, 1400-1401
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