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Science 11 March 1960:
Vol. 131. no. 3402, pp. 737 - 738
DOI: 10.1126/science.131.3402.737
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Articles

Autoradiographic Investigation of Incorporation of H3-Thymidine into Cells of the Rat and Mouse

Brigitte Schultze 1 and Wolfgang Oehlert 1

1 Institut für Medizinische Isotopenforschung der Universität Köln, Cologne, Germany

The application of H3-thymidine results in labeling of those nuclei of cells in which deoxyribonucleic acid (DNA) is synthesized during the interval between application and the sacrifice of tne animal (1-3). This paper reports autoradiographic investigation with H3-thymidine of rats and mice. This method permits a more exact statement of the number of dividing cells than does the microscopic estimate of mitosis. The latter method is practically impossible in tissues with small fusiform cells. Moreover, it is possible to obtain information about the relative time of DNA synthesis in different cells.


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Kinetics of Deoxyribonucleic Acid Synthesis within the Inner Enamel Epithelium.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)