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Science 11 December 1959:
Vol. 130. no. 3389, pp. 1653 - 1654
DOI: 10.1126/science.130.3389.1653
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Articles

Stimulation of Amino Acid Transport in Isolated Diaphragm by Growth Hormone Added in vitro

J. L. KOSTYO 1, J. HOTCHKISS 1, and E. KNOBIL 1

1 Department of Physiology, Harvard Medical School, Boston, Massachusetts

The influence of the pituitary on the transport of agr-aminoisobutyric acid-1-C14 into the cells of isolated rat diaphragm was investigated. Hypophysectomy results in a lower-than-normal rate of agr-aminoisobutyric acid-1-C14 penetration into muscle. Adding either simian or bovine growth hormone preparations to the incubation medium in concentrations of 2.5 to 25 µg/ml of medium resulted in a doubling of the agr-aminoisobutyric acid-l-C14 penetration rate. The stimulatory effect was minimized when the hormone concentration was reduced to 0.25 µg/ml of medium.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)