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Science 11 September 1959:
Vol. 130. no. 3376, pp. 628 - 629
DOI: 10.1126/science.130.3376.628
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Articles

Sublimation Freeze-Drying without Vacuum

H. T. MERYMAN 1

1 Biophysics Division, Naval Medical Research Institute, National Naval Medical Center, Bethesda, Maryland

Analysis of the freeze-drying procedure shows that the passage of water vapor from the drying boundary through the dried shell is facilitated primarily by the vapor pressure gradient rather than by the absolute pressure of the system. This is experimentally confirmed, and a device for freeze-drying at atmospheric pressure is described.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)