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Science 5 June 1959:
Vol. 129. no. 3362, p. 1553
DOI: 10.1126/science.129.3362.1553
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Articles

Phenylpyruvic Acid as a Possible Precursor of o-Hydroxyphenylacetic Acid in Man

RICHARD E. TASHIAN 1

1 Department of Human Genetics, University of Michigan Medical School, Ann Arbor

The oral administration of phenylpyruvic acid to human subjects results in increased urinary excretion of o-hydroxyphenylacetic acid. This demonstrates that phenylpyruvic acid may act as a precursor for o-hydroxy derivatives of phenylalanine and suggests that the formation of o-tyrosine is not necessary to account for the excretion of o-hydroxyphenylacetic acid in phenylketonuria.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Skin and Muscle Indurations in Phenylketonuria.
S. Jablonska, A. Stachow, and M. Suffczynska (1967)
Arch Dermatol 95, 443-450
   Abstract »    PDF »
Occult Phenylketonuria.
C. C. Mabry, T. L. Nelson, and F. A. Horner (1962)
Clinical Pediatrics 1, 82-86
   PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)