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Science 22 May 1959:
Vol. 129. no. 3360, pp. 1427 - 1428
DOI: 10.1126/science.129.3360.1427
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Articles

Antagonism of Veratrine by Calcium Ion in Monolayers of Stearic Acid

NORMAN L. GERSHFELD 1 and ABRAHAM M. SHANES 1

1 National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland

Force-area diagrams for monolayers of stearic acid on Ringer's solution demonstrate a competition between veratrine and calcium for carboxyl groups of the films. The competition occurs at customary concentrations. Local anesthetics act quite differently. The interactions suggest those observed less directly in living cells and therefore indicate that such surface films may serve as models for the study of drug and ion effects.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Membrane Permeability: Monolayer Relationships.
A. M. Shanes (1963)
Science 140, 824-825
   Abstract »    PDF »
Effects of Veratrine and Cocaine on Cerebral Carbohydrate-Amino Acid Interrelations.
M. M. Kini and J. H. Quastel (1960)
Science 131, 412-414
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)