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Science 17 April 1959:
Vol. 129. no. 3355, pp. 1025 - 1026
DOI: 10.1126/science.129.3355.1025
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Articles

Development of a Chick Embryo Heart Cell for the Cultivation of Poliovirus

J. E. PRIER 1 and R. SULLIVAN 1

1 Biological Development Department, Merck Sharp and Dohme, West Point, Pennsylvania

An epithelial-like cell has been developed in line culture that apparently is stable. Although initially isolated cells were incapable of supporting the growth of poliovirus, the cells of the sixth and later passages allowed virus to propagate. The early, nonsusceptible cells were fibroblastic in appearance, in contrast to the epithelial type, poliovirussusceptible, derived cell of later passages.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)