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Science 10 April 1959:
Vol. 129. no. 3354, pp. 968 - 969
DOI: 10.1126/science.129.3354.968
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Articles

Interference with Feedback Control: a Mechanism of Antimetabolite Action

H. S. MOYED 1 and MILDRED FRIEDMAN 1

1 Department of Bacteriology and Immunology, Harvard Medical School, Boston, Massachusetts

The action of an enzyme essential for tryptophan biosynthesis is inhibited by tryptophan and also by an analog of tryptophan. Similarly, histidine and one of its analogs inhibit the action of an enzyme essential for histidine biosynthesis. A mutant resistant to the histidine analog produces an apparently altered enzyme which is insensitive to both the analog and histidine.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Interference with Feedback Control of Enzyme Activity.
H. S. Moyed (1961)
Cold Spring Harb Symp Quant Biol 26, 323-329
   Abstract »    PDF »
Induced Phenotypic Resistance to an Antimetabolite.
H. S. Moyed (1960)
Science 131, 1449
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)