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Science 13 March 1959:
Vol. 129. no. 3350, p. 720
DOI: 10.1126/science.129.3350.720

Articles

New Method for the Rapid Determination of Lathyrogenic Agents

BARNET M. LEVY 1

1 University of Texas Dental Branch, Houston

Salamander and toad embryos will develop grossly observable tumors of the notochord if they are placed for 3 or more days in a solution of the lathyrism-producing chemicals beta-aminopropionitrile or aminoacetonitrile. A technique for using tumorigenesis in amphibian embryos as a biological indicator for other lathyrogenic agents is presented.





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Science. ISSN 0036-8075 (print), 1095-9203 (online)