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Science 9 January 1959:
Vol. 129. no. 3341, pp. 95 - 96
DOI: 10.1126/science.129.3341.95
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Articles

Studies on 4-Keto-L-Proline

CHOZO MITOMA 1, THOMAS E. SMITH 1, FRANCES M. DACOSTA 1, SIDNEY UDENFRIEND 1, ARTHUR A. PATCHETT 2, and BERNHARD WITKOP 2

1 National Heart Institute, National Institutes of Health, Bethesda, Maryland
2 National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland

The administration of ketoproline to chick embryos resulted in an increase in the free hydroxyproline. This phenomenon is explained by the inhibitory action of ketoproline on the catabolism of hydroxyproline as well as by the conversion of the former to the latter. Ketoproline was found to be reduced to hydroxyproline by the supernatant fraction of rat-kidney homogenate in the presence of a reduced pyridine nucleotide.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)