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Science 19 December 1958:
Vol. 128. no. 3338, pp. 1572 - 1574
DOI: 10.1126/science.128.3338.1572-a
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Articles

Correlation of Drug Penetration of Brain and Chemical Structure

A. H. SOLOWAY 1

1 Department of Neurosurgery, Massachusetts General Hospital, Boston

A study has been carried out on the permeability of the brain and a brain tumor to certain aromatic boronic acids with regard to their use in the neutron capture therapy of gliomas. The penetration of the brain by these compounds is discussed as a function of chemical substituent and benzene-aqueous partition coefficient.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)