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Science 21 November 1958:
Vol. 128. no. 3334, pp. 1279 - 1280
DOI: 10.1126/science.128.3334.1279
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Articles

Demethylation of Chlorpromazine-(N-Methyl)-C14

JOHN J. Ross JR. 1, RICHARD L. YOUNG 1, and ALFRED R. MAASS 1

1 Smith, Kline, and French Laboratories, Philadelphia, Pennsylvania

Chlorpromazine methyl-C14 was administered to three groups of rats—orally to one group following chronic oral administration of the unlabeled drug; orally to an unprimed group; and intravenously to another unprimed group. Appearance of C14O2 in the air expired by all animals indicated that the rat metabolized the side chain of the labeled drug.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Urinary Thorazine Metabolites in Psychotic Patients.
C. LI HUANG, F. L. SANDS, and A. A. KURLAND (1963)
Arch Gen Psychiatry 8, 301-307
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Science. ISSN 0036-8075 (print), 1095-9203 (online)