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Submitted on September 23, 2008
Accepted on December 19, 2008
A Kinase-START Gene Confers Temperature-Dependent Resistance to Wheat Stripe Rust
Daolin Fu 1,Cristobal Uauy 2,Assaf Distelfeld 3,Ann Blechl 4,Lynn Epstein 5,Xianming Chen 6,Hanan Sela 7,Tzion Fahima 7,Jorge Dubcovsky 8*
1 Department of Plant Sciences, University of California, Davis, CA 95616, USA.; Present address: Department of Agronomy, Shandong Agricultural University, Tai’an, Shandong 271018, China. 2 Department of Plant Sciences, University of California, Davis, CA 95616, USA.; Present address: John Innes Centre, Colney, Norwich NR4 7UH, UK. 3 Department of Plant Sciences, University of California, Davis, CA 95616, USA.; Department of Evolutionary and Environmental Biology, University of Haifa, Haifa 31905, Israel. 4 USDA-ARS, Western Regional Research Center, Albany, CA 94710, USA. 5 Department of Plant Pathology, University of California, Davis, CA 95616, USA. 6 USDA-ARS and Department of Plant Pathology, Washington State University, Pullman, WA 99164, USA. 7 Department of Evolutionary and Environmental Biology, University of Haifa, Haifa 31905, Israel. 8 Department of Plant Sciences, University of California, Davis, CA 95616, USA.
* To whom correspondence should be addressed.
Jorge Dubcovsky , E-mail: jdubcovsky{at}ucdavis.edu
These authors contributed equally to this work.
Stripe rust is a devastating fungal disease that afflicts wheatin many regions of the world. New races of Puccinia striiformis,the pathogen responsible for this disease, have overcome mostof the known race-specific resistance genes. We report herethe map-based cloning of the gene Yr36 (WKS1), which confersbroad-race resistance to stripe rust at relatively high temperatures(25 to 35°C). This gene includes a kinase and a putativeSTART lipid-binding domain. Five independent mutations and transgeniccomplementation confirmed that both domains are necessary toconfer resistance. Yr36 is present in wild wheat but absentin modern pasta and bread wheat varieties and therefore, cannow be used to improve resistance to stripe rust in a broadset of varieties.
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Simon G. Krattinger, Evans S. Lagudah, Wolfgang Spielmeyer, Ravi P. Singh, Julio Huerta-Espino, Helen McFadden, Eligio Bossolini, Liselotte L. Selter, and Beat Keller (6 March 2009) Science323 (5919), 1360.
[DOI: 10.1126/science.1166453] |Abstract »|Full Text »|PDF »|Supporting Online Material »
PERSPECTIVES
Daniel J. Kliebenstein and Heather C. Rowe (6 March 2009) Science323 (5919), 1301.
[DOI: 10.1126/science.1171410] |Summary »|Full Text »|PDF »
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