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Published Online August 21, 2008
Science DOI: 10.1126/science.1160038

Reports

Submitted on May 5, 2008
Accepted on August 13, 2008

Chemokine Signaling Controls Endodermal Migration During Zebrafish Gastrulation

Sreelaja Nair 1 and Thomas F. Schilling 1*

1 Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA.

* To whom correspondence should be addressed.
Thomas F. Schilling , E-mail: tschilli{at}uci.edu

Directed cell movements during gastrulation establish the germ layers of the vertebrate embryo and coordinate their contributions to different tissues and organs. Anterior migration of mesoderm and endoderm has largely been interpreted to result from epiboly and convergent-extension movements that drive body elongation. We show that the chemokine cxcl12b and its receptor Cxcr4A restrict anterior migration of endoderm during zebrafish gastrulation, thereby coordinating its movements with mesoderm. Depletion of either gene product causes the endoderm to separate from mesoderm and migrate farther anterior than normal, due to disruption of integrin-dependent cell adhesion. This results in bilateral duplications of endodermal organs, which may have relevance to human organ defects.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Chemokine signaling guides regional patterning of the first embryonic artery.
A. F. Siekmann, C. Standley, K. E. Fogarty, S. A. Wolfe, and N. D. Lawson (2009)
Genes & Dev. 23, 2272-2277
   Abstract »    Full Text »    PDF »
Chemokine signaling in embryonic cell migration: a fisheye view.
E. Raz and H. Mahabaleshwar (2009)
Development 136, 1223-1229
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)