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Submitted on January 14, 2008
Accepted on April 11, 2008
Coordination of Early Protective Immunity to Viral Infection by Regulatory T Cells
Jennifer M. Lund 1,Lianne Hsing 1,Thuy T. Pham 1,Alexander Y. Rudensky 1*
1 Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.
* To whom correspondence should be addressed.
Alexander Y. Rudensky , E-mail: aruden{at}u.washington.edu
Suppression of immune responses by regulatory T cells (Treg)is thought to limit late stages of pathogen-specific immunityas a means of minimizing associated tissue damage. Here, weexamined a role for Tregs during mucosal HSV infection, andobserve an accelerated fatal infection with increased viralloads in the mucosa and central nervous system after ablationof Tregs. Although augmented interferon production was detectedin the draining lymph nodes (dLN) in Treg-deprived mice, itwas profoundly reduced at the infection site. This was associatedwith a delay in the arrival of natural killer cells, dendriticcells, and T cells to the site of infection and a sharp increasein pro-inflammatory chemokine levels in the dLNs. Our resultssuggest that Tregs facilitate early protective responses tolocal viral infection by allowing a timely entry of immune cellsinto infected tissue.
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