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Submitted on June 20, 2007
Accepted on September 27, 2007
The Arabidopsis Circadian Clock Incorporates a cADPR-Based Feedback Loop
Antony N. Dodd 1,Michael J. Gardner 1,Carlos T. Hotta 1,Katharine E. Hubbard 1,Neil Dalchau 1,John Love 2,Jean-Maurice Assie 1,Fiona C. Robertson 1,Mia Kyed Jakobsen 3,Jorge Gonçalves 4,Dale Sanders 5,Alex A. R. Webb 1*
1 Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, UK. 2 Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, UK.; Present address: School of Biosciences, Geoffrey Pope Building, University of Exeter EX4 4QD, UK. 3 Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, UK.; Present address: Institute for Plant Biology, Copenhagen University, Thorvaldsensvej 40, 1871 Frederiksberg, Denmark. 4 Department of Engineering, University of Cambridge, Trumpington Street, Cambridge CB2 1PZ, UK. 5 Department of Biology, University of York, York YO10 5YW, UK.
* To whom correspondence should be addressed.
Alex A. R. Webb , E-mail: alex.webb{at}plantsci.cam.ac.uk
Transcriptional feedback loops are a feature of circadian clocksin both animals and plants. We show that the plant circadianclock also incorporates the cytosolic signaling molecule cyclicadenosine diphosphate ribose (cADPR). cADPR modulates the circadianoscillator's transcriptional feedback loops and drives circadianoscillations of Ca2+ release. The effects of antagonists ofcADPR signaling, manipulation of cADPR synthesis, and mathematicalsimulation of the interaction of cADPR with the circadian clockindicate that cADPR forms a feedback loop within the plant circadianclock.
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