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Submitted on May 5, 2006
Accepted on July 25, 2006
Human IRGM Induces Autophagy to Eliminate Intracellular Mycobacteria
Sudha B. Singh 1, Alexander S. Davis 1, Gregory A. Taylor 2, Vojo Deretic 3*
1 Departments of Molecular Genetics and Microbiology 2 Departments of Medicine, Molecular Genetics & Microbiology, and Immunology and Center for the Study of Aging, Duke University, Durham, NC 27710, USA; GRECC, VA Medical Center, Durham, NC 27710, USA. 3 Departments of Molecular Genetics and Microbiology; Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.
* To whom correspondence should be addressed.
Vojo Deretic , E-mail: vderetic{at}salud.unm.edu
Immunity related p47 GTPases (IRG) play a role in defense againstintracellular pathogens. Here we found that the murine Irgm1(LRG-47) GTPase induced autophagy and generated large autolysosomalorganelles as a mechanism for elimination of intracellular Mycobacteriumtuberculosis. We also found a role for a human IRG protein inthe control of intracellular pathogens, and report that thehuman Irgm1 ortholog, IRGM, plays a role in autophagy and reductionof intracellular bacillary load.
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