Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Published Online August 17, 2006
Science DOI: 10.1126/science.1128232

Reports

Submitted on April 3, 2006
Accepted on July 31, 2006

PirB Restricts Ocular-Dominance Plasticity in Visual Cortex

Josh Syken 1, Tadzia GrandPre 1, Patrick O. Kanold 1, Carla J. Shatz 1*

1 Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.

* To whom correspondence should be addressed.
Carla J. Shatz , E-mail: carla_shatz{at}hms.harvard.edu

Experience can alter synaptic connectivity throughout life, but the degree of plasticity present at each age is regulated by mechanisms that remain largely unknown. Here we demonstrate that PirB, an MHC Class I (MHCI) receptor, is expressed in subsets of neurons throughout the brain. Neuronal PirB protein is associated with synapses and forms complexes with the phosphatases Shp-1 and Shp-2. Soluble PirB fusion protein binds to cortical neurons in an MHCI-dependent manner. In mutant mice lacking functional PirB, cortical ocular dominance (OD) plasticity is more robust at all ages. Thus, an MHCI receptor is expressed in CNS neurons and functions to limit the extent of experience-dependent plasticity in the visual cortex throughout life. PirB is also expressed in many other regions of the CNS, suggesting that it may function broadly to stabilize neural circuits.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
No Nogo66- and NgR-Mediated Inhibition of Regenerating Axons in the Zebrafish Optic Nerve.
H. Abdesselem, A. Shypitsyna, G. P. Solis, V. Bodrikov, and C. A. O. Stuermer (2009)
J. Neurosci. 29, 15489-15498
   Abstract »    Full Text »    PDF »
Nogo receptor 1 regulates formation of lasting memories.
A. Karlen, T. E. Karlsson, A. Mattsson, K. Lundstromer, S. Codeluppi, T. M. Pham, C. M. Backman, S. O. Ogren, E. Aberg, A. F. Hoffman, et al. (2009)
PNAS 106, 20476-20481
   Abstract »    Full Text »    PDF »
Classical Major Histocompatibility Complex Class I Molecules in Motoneurons: New Actors at the Neuromuscular Junction.
S. Thams, P. Brodin, S. Plantman, R. Saxelin, K. Karre, and S. Cullheim (2009)
J. Neurosci. 29, 13503-13515
   Abstract »    Full Text »    PDF »
The Development of Developmental Neuroscience.
C. Mason (2009)
J. Neurosci. 29, 12735-12747
   Full Text »    PDF »
Co-regulation of ocular dominance plasticity and NMDA receptor subunit expression in glutamic acid decarboxylase-65 knock-out mice.
P. O. Kanold, Y. A. Kim, T. GrandPre, and C. J. Shatz (2009)
J. Physiol. 587, 2857-2867
   Abstract »    Full Text »    PDF »
Fragile Axons Forge the Path to Gene Discovery: A MAP Kinase Pathway Regulates Axon Regeneration.
G. S. O'Brien and A. Sagasti (2009)
Science Signaling 2, pe30
   Abstract »    Full Text »    PDF »
H2-Kb and H2-Db regulate cerebellar long-term depression and limit motor learning.
M. J. McConnell, Y. H. Huang, A. Datwani, and C. J. Shatz (2009)
PNAS 106, 6784-6789
   Abstract »    Full Text »    PDF »
Molecular mechanisms of experience-dependent plasticity in visual cortex.
D. Tropea, A. Van Wart, and M. Sur (2009)
Phil Trans R Soc B 364, 341-355
   Abstract »    Full Text »    PDF »
PirB is a Functional Receptor for Myelin Inhibitors of Axonal Regeneration.
J. K. Atwal, J. Pinkston-Gosse, J. Syken, S. Stawicki, Y. Wu, C. Shatz, and M. Tessier-Lavigne (2008)
Science 322, 967-970
   Abstract »    Full Text »    PDF »
Afferent Deprivation Elicits a Transcriptional Response Associated with Neuronal Survival after a Critical Period in the Mouse Cochlear Nucleus.
J. A. Harris, F. Iguchi, A. H. Seidl, D. I. Lurie, and E. W Rubel (2008)
J. Neurosci. 28, 10990-11002
   Abstract »    Full Text »    PDF »
PIR-B-Deficient Mice Are Susceptible to Salmonella Infection.
I. Torii, S. Oka, M. Hotomi, W. H. Benjamin Jr, T. Takai, J. F. Kearney, D. E. Briles, and H. Kubagawa (2008)
J. Immunol. 181, 4229-4239
   Abstract »    Full Text »    PDF »
Highly Selective Receptive Fields in Mouse Visual Cortex.
C. M. Niell and M. P. Stryker (2008)
J. Neurosci. 28, 7520-7536
   Abstract »    Full Text »    PDF »
Gene expression patterns in visual cortex during the critical period: Synaptic stabilization and reversal by visual deprivation.
(2008)
PNAS 105, 9409-9414
Cutting Edge: MHC Class I-Ly49 Interaction Regulates Neuronal Function.
O. Zohar, Y. Reiter, J. R. Bennink, A. Lev, S. Cavallaro, S. Paratore, C. G. Pick, G. Brooker, and J. W. Yewdell (2008)
J. Immunol. 180, 6447-6451
   Abstract »    Full Text »    PDF »
Expression of Nonclassical Class I Major Histocompatibility Genes Defines a Tripartite Organization of the Mouse Vomeronasal System.
T. Ishii and P. Mombaerts (2008)
J. Neurosci. 28, 2332-2341
   Abstract »    Full Text »    PDF »
CD3 and Immunoglobulin G Fc Receptor Regulate Cerebellar Functions.
K. Nakamura, H. Hirai, T. Torashima, T. Miyazaki, H. Tsurui, Y. Xiu, M. Ohtsuji, Q. S. Lin, K. Tsukamoto, H. Nishimura, et al. (2007)
Mol. Cell. Biol. 27, 5128-5134
   Abstract »    Full Text »    PDF »
Regulation of CNS synapses by neuronal MHC class I.
C. A. Goddard, D. A. Butts, and C. J. Shatz (2007)
PNAS 104, 6828-6833
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)