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Submitted on January 30, 2006
Accepted on March 21, 2006
H5N1 Virus Attachment to Lower Respiratory Tract
Debby van Riel 1, Vincent J. Munster 1, Emmie de Wit 1, Guus F. Rimmelzwaan 1, Ron A. M. Fouchier 1, Ab D. M. E. Osterhaus 1, Thijs Kuiken 1*
1 Department of Virology, Erasmus Medical Center, 3015 GE Rotterdam, Netherlands.
* To whom correspondence should be addressed.
Thijs Kuiken , E-mail: t.kuiken{at}erasmusmc.nl
Highly pathogenic avian influenza virus (H5N1) may cause severelower respiratory tract (LRT) disease in humans. However, theLRT cells to which the virus attaches are unknown for both humansand other mammals. We showed that H5N1 virus attached predominantlyto type II pneumocytes, alveolar macrophages, and non-ciliatedbronchiolar cells in human LRT and that this pattern was mostclosely mirrored in cat and ferret tissues. These findings mayexplain, at least in part, the localization and severity ofH5N1 viral pneumonia in humans. They also identify the cat andthe ferret as suitable experimental animals based on this criterion.
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