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Published Online February 2, 2006
Science DOI: 10.1126/science.1122446

Brevia

Submitted on November 10, 2005
Accepted on January 3, 2006

Cellular Senescence in Aging Primates

Utz Herbig 1, Mark Ferreira 1, Laura Condel 2, Dee Carey 2, John M. Sedivy 1*

1 Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02903, USA.
2 Department of Comparative Medicine, Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA.

* To whom correspondence should be addressed.
John M. Sedivy , E-mail: john_sedivy{at}brown.edu

Aging of organisms is characterized by a gradual functional decline of all organ systems. Mammalian somatic cells in culture display a limited proliferative life span, at the end of which they undergo an irreversible cell cycle arrest known as replicative senescence. Whether cellular senescence contributes to organismal aging has been controversial. We investigated telomere dysfunction, a recently discovered biomarker of cellular senescence, and found that the number of senescent fibroblasts increases exponentially in the skin of aging baboons, reaching values of >15% in very old individuals. In addition, the same cells contain activated ataxia-telangiectasia mutated (ATM) kinase and heterochromatinized nuclei, confirming their senescent status.


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