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Published Online December 1, 2005
Science DOI: 10.1126/science.1117729

Reports

Submitted on July 21, 2005
Accepted on November 17, 2005

A Clonogenic Bone Marrow Progenitor Specific for Macrophages and Dendritic Cells

Darin K. Fogg 1, Claire Sibon 1, Chaouki Miled 1, Steffen Jung 2, Pierre Aucouturier 3, Dan R. Littman 4, Ana Cumano 5, Frederic Geissmann 6*

1 INSERM, Laboratory of Mononuclear Phagocyte Biology, Avenir Team, Necker Enfants Malades institute, Paris, France EU.
2 Department of Immunology, the Weizmann Institute of Science, Rehovot, Israel.
3 INSERM U712, Paris, France.
4 Howard Hughes Medical Institute, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016 USA.
5 INSERM, U668, Paris, France; Institut Pasteur, Lymphocyte Development Unit, Paris, France.
6 INSERM, Laboratory of Mononuclear Phagocyte Biology, Avenir Team, Necker Enfants Malades institute, Paris, France EU; Pathology Department, Necker Enfants Malades Hospital, University of Paris-Descartes Faculty of Medicine & AP HP, Paris, France EU.

* To whom correspondence should be addressed.
Frederic Geissmann , E-mail: geissman{at}necker.fr

Macrophages and dendritic cells (DC) are crucial for immune and inflammatory response, and belong to a network of cells that has been termed the mononuclear phagocyte system (MPS). However, the origin and lineage relationship of these cells remains poorly understood. Here we describe the isolation and clonal analysis of a bone marrow progenitor that is specific for monocytes, several macrophages subsets, and resident spleen DC in vivo. It was also possible to recapitulate this differentiation in vitro using treatment with the cytokines M-CSF and GM-CSF. Thus, macrophages and DC appear to renew from a common progenitor, providing a cellular and molecular basis for the concept of the MPS.


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