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Published Online September 1, 2005
Science DOI: 10.1126/science.1115791

Reports

Submitted on June 7, 2005
Accepted on August 23, 2005

Movement of Eukaryotic mRNAs Between Polysomes and Cytoplasmic Processing Bodies

Muriel Brengues 1, Daniela Teixeira 1, Roy Parker 1*

1 Department of Molecular and Cellular Biology & Howard Hughes Medical Institute, University of Arizona, Tucson, AZ, 85721-0106, USA.

* To whom correspondence should be addressed.
Roy Parker , E-mail: rrparker{at}u.arizona.edu

Eukaryotic cells contain non-translating mRNA concentrated in P-bodies, which are sites where the mRNA can be decapped and degraded. We present evidence that mRNAs within yeast P-bodies can also return to translation. First, inhibiting delivery of new mRNAs to P-bodies leads to their disassembly independent of mRNA decay. Second, P-bodies decline in a translation initiation-dependent manner during stress recovery. Third, reporter mRNAs concentrate in P-bodies when translation initiation is blocked and resume translation and exit P-bodies when translation is restored. Fourth, stationary phase yeast have large P-bodies containing mRNAs that re-enter translation when growth resumes. The reciprocal movement of mRNAs between polysomes and P-bodies is likely to be important in the control of mRNA translation and degradation. Moreover, because P-bodies and maternal mRNA storage granules contain related proteins, it suggests this mechanism has been widely adapted for mRNA storage.


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