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Submitted on March 5, 2005
Accepted on March 9, 2005
Was the Human Genome Project Worth the Effort?
Stephen P. Daiger 1*
1 Human Genetics Center, the University of Texas Health Sciences Center, Houston, TX 77030, USA.
* To whom correspondence should be addressed.
Stephen P. Daiger , E-mail: stephen.p.daiger{at}uth.tmc.edu
The Human Genome Project is much more than the genetic map ofour species. It is also a powerful set of integrated tools forsolving problems in medicine and biology. Application of thesetools to a common cause of human blindness, age-related maculardegeneration, implicates a common variant in the gene encodingcomplement factor H as a major contributor to the risk of developingthis disease (Klein et al., Haines et al., Edwards et al.). The new findings raise hopes for better diagnosis and treatmentof macular degeneration and further validate the importanceof the Human Genome Project.
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In Science Magazine
RESEARCH ARTICLES
Robert J. Klein, Caroline Zeiss, Emily Y. Chew, Jen-Yue Tsai, Richard S. Sackler, Chad Haynes, Alice K. Henning, John Paul SanGiovanni, Shrikant M. Mane, Susan T. Mayne, Michael B. Bracken, Frederick L. Ferris, Jurg Ott, Colin Barnstable, and Josephine Hoh (15 April 2005) Science308 (5720), 385.
[DOI: 10.1126/science.1109557] |Abstract »|Full Text »|PDF »|Supporting Online Material »
REPORTS
Albert O. Edwards, Robert Ritter, III, Kenneth J. Abel, Alisa Manning, Carolien Panhuysen, and Lindsay A. Farrer (15 April 2005) Science308 (5720), 421.
[DOI: 10.1126/science.1110189] |Abstract »|Full Text »|PDF »|Supporting Online Material »
REPORTS
Jonathan L. Haines, Michael A. Hauser, Silke Schmidt, William K. Scott, Lana M. Olson, Paul Gallins, Kylee L. Spencer, Shu Ying Kwan, Maher Noureddine, John R. Gilbert, Nathalie Schnetz-Boutaud, Anita Agarwal, Eric A. Postel, and Margaret A. Pericak-Vance (15 April 2005) Science308 (5720), 419.
[DOI: 10.1126/science.1110359] |Abstract »|Full Text »|PDF »|Supporting Online Material »
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