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Published Online February 10, 2005
Science DOI: 10.1126/science.1106943

Reports

Submitted on November 1, 2004
Accepted on January 6, 2005

A Transmembrane Intracellular Estrogen Receptor Mediates Rapid Cell Signaling

Chetana M. Revankar 1, Daniel F. Cimino 1, Larry A. Sklar 2, Jeffrey B. Arterburn 3, Eric R. Prossnitz 1*

1 Department of Cell Biology and Physiology; Cancer Research and Treatment Center
2 Cancer Research and Treatment Center; Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
3 Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, NM 88003, USA.

* To whom correspondence should be addressed.
Eric R. Prossnitz , E-mail: eprossnitz{at}salud.unm.edu

The steroid hormone estrogen regulates many functionally unrelated processes in numerous tissues. Although it is traditionally thought to control transcriptional activation through the classical nuclear estrogen receptors, it also initiates many rapid nongenomic signaling events. We found that of all G protein-coupled receptors characterized to date, GPR30 is uniquely localized to the endoplasmic reticulum, where it specifically binds estrogen and fluorescent estrogen derivatives. Activating GPR30 by estrogen resulted in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. Thus, GPR30 represents an intracellular transmembrane estrogen receptor that may contribute to normal estrogen physiology as well as pathophysiology.


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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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V. Bourdeau, J. Deschenes, D. Laperriere, M. Aid, J. H. White, and S. Mader (2008)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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A. S. Chagin and L. Savendahl (2007)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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K. S. Monkkonen, R. Aflatoonian, K.-F. Lee, W. S.B. Yeung, S.-W. Tsao, J. T. Laitinen, and A. Fazeli (2007)
Mol. Hum. Reprod. 13, 845-851
   Abstract »    Full Text »    PDF »
Vasorelaxant action of 17 -estradiol in rat uterine arteries: role of nitric oxide synthases and estrogen receptors.
P.-A. Scott, A. Tremblay, M. Brochu, and J. St-Louis (2007)
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   Abstract »    Full Text »    PDF »
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R. Alzamora, L. R. Brown, and B. J. Harvey (2007)
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   Abstract »    Full Text »    PDF »
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   Abstract »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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M. I. Boulware, H. Kordasiewicz, and P. G. Mermelstein (2007)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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J. Endocrinol. 194, 193-200
   Abstract »    Full Text »    PDF »
Activation of the Novel Estrogen Receptor G Protein-Coupled Receptor 30 (GPR30) at the Plasma Membrane.
E. Filardo, J. Quinn, Y. Pang, C. Graeber, S. Shaw, J. Dong, and P. Thomas (2007)
Endocrinology 148, 3236-3245
   Abstract »    Full Text »    PDF »
Direct Interactions with G{alpha}i and G{beta}{gamma} Mediate Nongenomic Signaling by Estrogen Receptor {alpha}.
P. Kumar, Q. Wu, K. L. Chambliss, I. S. Yuhanna, S. M. Mumby, C. Mineo, G. G. Tall, and P. W. Shaul (2007)
Mol. Endocrinol. 21, 1370-1380
   Abstract »    Full Text »    PDF »
Salutary effects of 17beta-estradiol on T-cell signaling and cytokine production after trauma-hemorrhage are mediated primarily via estrogen receptor-{alpha}.
T. Suzuki, T. Shimizu, H.-P. Yu, Y.-C. Hsieh, M. A. Choudhry, and I. H. Chaudry (2007)
Am J Physiol Cell Physiol 292, C2103-C2111
   Abstract »    Full Text »    PDF »
Differential Effects of 17{beta}-Estradiol on Function and Expression of Estrogen Receptor {alpha}, Estrogen Receptor {beta}, and GPR30 in Arteries and Veins of Patients With Atherosclerosis.
E. Haas, M. R. Meyer, U. Schurr, I. Bhattacharya, R. Minotti, H. H. Nguyen, A. Heigl, M. Lachat, M. Genoni, and M. Barton (2007)
Hypertension 49, 1358-1363
   Abstract »    Full Text »    PDF »
Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system.
E. Brailoiu, S. L Dun, G C. Brailoiu, K. Mizuo, L. A Sklar, T. I Oprea, E. R Prossnitz, and N. J Dun (2007)
J. Endocrinol. 193, 311-321
   Abstract »    Full Text »    PDF »
G Protein-Coupled Receptor 30-Dependent Protein Kinase A Pathway Is Critical in Nongenomic Effects of Estrogen in Attenuating Liver Injury after Trauma-Hemorrhage.
Y.-C. Hsieh, H.-P. Yu, M. Frink, T. Suzuki, M. A. Choudhry, M. G. Schwacha, and I. H. Chaudry (2007)
Am. J. Pathol. 170, 1210-1218
   Abstract »    Full Text »    PDF »
Nongenomic Actions of Aldosterone on the Renal Tubule.
D. W. Good (2007)
Hypertension 49, 728-739
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The Role of Xenopus Membrane Progesterone Receptor {beta} in Mediating the Effect of Progesterone on Oocyte Maturation.
L. Josefsberg Ben-Yehoshua, A. L. Lewellyn, P. Thomas, and J. L. Maller (2007)
Mol. Endocrinol. 21, 664-673
   Abstract »    Full Text »    PDF »
G Protein-Coupled Receptor 30 (GPR30) Mediates Gene Expression Changes and Growth Response to 17{beta}-Estradiol and Selective GPR30 Ligand G-1 in Ovarian Cancer Cells.
L. Albanito, A. Madeo, R. Lappano, A. Vivacqua, V. Rago, A. Carpino, T. I. Oprea, E. R. Prossnitz, A. M. Musti, S. Ando, et al. (2007)
Cancer Res. 67, 1859-1866
   Abstract »    Full Text »    PDF »
Membrane-Initiated Actions of Estrogens in Neuroendocrinology: Emerging Principles.
N. Vasudevan and D. W. Pfaff (2007)
Endocr. Rev. 28, 1-19
   Abstract »    Full Text »    PDF »
Estrogenic Agonist Activity of ICI 182,780 (Faslodex) in Hippocampal Neurons: Implications for Basic Science Understanding of Estrogen Signaling and Development of Estrogen Modulators with a Dual Therapeutic Profile.
L. Zhao, K. O'Neill, and R. D. Brinton (2006)
J. Pharmacol. Exp. Ther. 319, 1124-1132
   Abstract »    Full Text »    PDF »
Human Homologs of the Putative G Protein-Coupled Membrane Progestin Receptors (mPR{alpha}, {beta}, and {gamma}) Localize to the Endoplasmic Reticulum and Are Not Activated by Progesterone.
T. Krietsch, M. S. Fernandes, J. Kero, R. Losel, M. Heyens, E. W.-F. Lam, I. Huhtaniemi, J. J. Brosens, and B. Gellersen (2006)
Mol. Endocrinol. 20, 3146-3164
   Abstract »    Full Text »    PDF »
Estrogen Receptor-Mediated Rapid Signaling.
K. Moriarty, K. H. Kim, and J. R. Bender (2006)
Endocrinology 147, 5557-5563
   Abstract »    Full Text »    PDF »
Rapid Glucocorticoid Signaling via Membrane-Associated Receptors.
J. G. Tasker, S. Di, and R. Malcher-Lopes (2006)
Endocrinology 147, 5549-5556
   Abstract »    Full Text »    PDF »


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