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Published Online August 26, 2004
Science DOI: 10.1126/science.1102421

Reports

Submitted on July 7, 2004
Accepted on August 9, 2004

Soma-Germ Line Competition for Lipid Phosphate Uptake Regulates Germ Cell Migration and Survival

A. D. Renault 1, Y. J. Sigal 2, A. J. Morris 2, R. Lehmann 1*

1 Howard Hughes Medical Institute and Skirball Institute of Biomolecular Medicine, Developmental Genetics Program, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA.
2 Department of Cell and Developmental Biology, Room 522, Taylor Hall, CB#7090, University of North Carolina at Chapel Hill, Chapel Hill NC 27599-7090, USA.

* To whom correspondence should be addressed.
R. Lehmann , E-mail: lehmann{at}saturn.med.nyu.edu

Lipid phosphates can act as signaling molecules to influence cell division, apoptosis and migration. wunen and wunen2 encode Drosophila lipid phosphate phosphohydrolases, integral membrane enzymes that dephosphorylate extracellular lipid phosphates. wun and wun2 act redundantly in somatic tissues to repel migrating germ cells, although the mechanism by which germ cells respond is unclear. Here we report that wun2 also functions in germ cells enabling them to perceive the wun/wun2-related signal from the soma. Upon Wun2 expression, cultured insect cells dephosphorylate and internalize exogenously supplied lipid phosphate. We propose that Drosophila germ cell migration and survival is controlled by competition for hydrolysis of a lipid phosphate between germ cells and soma.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)