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Submitted on July 7, 2004
Accepted on August 9, 2004
Soma-Germ Line Competition for Lipid Phosphate Uptake Regulates Germ Cell Migration and Survival
A. D. Renault 1, Y. J. Sigal 2, A. J. Morris 2, R. Lehmann 1*
1 Howard Hughes Medical Institute and Skirball Institute of Biomolecular Medicine, Developmental Genetics Program, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA. 2 Department of Cell and Developmental Biology, Room 522, Taylor Hall, CB#7090, University of North Carolina at Chapel Hill, Chapel Hill NC 27599-7090, USA.
* To whom correspondence should be addressed.
R. Lehmann , E-mail: lehmann{at}saturn.med.nyu.edu
Lipid phosphates can act as signaling molecules to influencecell division, apoptosis and migration. wunen and wunen2 encodeDrosophila lipid phosphate phosphohydrolases, integral membraneenzymes that dephosphorylate extracellular lipid phosphates.wun and wun2 act redundantly in somatic tissues to repel migratinggerm cells, although the mechanism by which germ cells respondis unclear. Here we report that wun2 also functions in germcells enabling them to perceive the wun/wun2-related signalfrom the soma. Upon Wun2 expression, cultured insect cells dephosphorylateand internalize exogenously supplied lipid phosphate. We proposethat Drosophila germ cell migration and survival is controlledby competition for hydrolysis of a lipid phosphate between germcells and soma.
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