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Published Online March 18, 2004
Science DOI: 10.1126/science.1097439

Perspectives

Submitted on March 11, 2004
Accepted on March 17, 2004

Oily Barbarians Breach Ion Channel Gates

Donald W. Hilgemann 1*

1 Department of Physiology, University of Texas Southwestern, Dallas, TX 75235, USA.

* To whom correspondence should be addressed. E-mail: donald.hilgemann{at}utsouthwestern.edu.

It has long been debated whether and how voltage-gated ion channels are affected by the lipid environment of the plasma membrane. In a Perspective, Hilgemann discusses new work (Oliver et al.) showing that the inactivation of voltage-gated potassium (Kv) channels can be modulated by the lipids PIP2 and arachidonic acid.


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