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Published Online December 18, 2003
Science DOI: 10.1126/science.1090782

Reports

Submitted on August 25, 2003
Accepted on November 21, 2003

Transformation of Olfactory Representations in the Drosophila Antennal Lobe

Rachel I. Wilson 1, Glenn C. Turner 1, Gilles Laurent 1*

1 Division of Biology, 139-74, California Institute of Technology, Pasadena, CA 91125, USA.

* To whom correspondence should be addressed. E-mail: laurentg{at}caltech.edu.

Molecular genetics has revealed a precise stereotypy in the projection of primary olfactory sensory neurons onto secondary neurons. A major challenge is to understand how this mapping translates into odor responses in these second-order neurons. We investigated this question in Drosophila using whole-cell recordings in vivo. We observe that mono-molecular odors generally elicit responses in large ensembles of antennal lobe neurons. Comparison of odor-evoked activity from afferents and postsynaptic neurons in the same glomerulus revealed that second-order neurons display broader tuning and more complex responses than their primary afferents. This indicates a major transformation of odor representations, implicating lateral interactions within the antennal lobe.


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