Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Published Online November 26, 2003
Science DOI: 10.1126/science.1090701

Research Articles

Submitted on August 22, 2003
Accepted on November 11, 2003

ATP-Driven Exchange of Histone H2AZ Variant Catalyzed by SWR1 Chromatin Remodeling Complex

Gaku Mizuguchi 1, Xuetong Shen 1, Joe Landry 1, Wei-Hua Wu 2, Subhojit Sen 2, Carl Wu 1*

1 Laboratory of Molecular Cell Biology, National Cancer Institute, National Institutes of Health, Building 37, Room 6068, Bethesda, MD 20892-4255, USA.
2 Laboratory of Molecular Cell Biology, National Cancer Institute, National Institutes of Health, Building 37, Room 6068, Bethesda, MD 20892-4255, USA; Present address: Department of Carcinogenesis, MD Anderson Cancer Center, Science Park Research Division, Smithville, TX 78957, USA.

* To whom correspondence should be addressed. E-mail: carlwu{at}helix.nih.gov.

The conserved histone variant H2AZ has an important role in the regulation of gene expression and the establishment of a buffer to the spread of silent heterochromatin. How histone variants such as H2AZ are incorporated into nucleosomes has been obscure. We have found that Swr1, a Swi2/Snf2-related ATPase, is the catalytic core of a multi-subunit, histone variant exchanger that efficiently replaces conventional histone H2A with histone H2AZ in nucleosome arrays. Swr1 is required for the deposition of histone H2AZ at specific chromosome locations in vivo, and Swr1 and H2AZ commonly regulate a subset of yeast genes. These findings define a new role for the ATP-dependent chromatin remodeling machinery.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Global analysis of mutual interaction surfaces of nucleosomes with comprehensive point mutants.
M. Sakamoto, S. Noguchi, S. Kawashima, Y. Okada, T. Enomoto, M. Seki, and M. Horikoshi (2009)
Genes Cells 14, 1271-1330
   Abstract »    Full Text »    PDF »
The Yeast RNA Polymerase II-associated Factor Iwr1p Is Involved in the Basal and Regulated Transcription of Specific Genes.
L. Peiro-Chova and F. Estruch (2009)
J. Biol. Chem. 284, 28958-28967
   Abstract »    Full Text »    PDF »
Cooperative action of TIP48 and TIP49 in H2A.Z exchange catalyzed by acetylation of nucleosomal H2A.
J. Choi, K. Heo, and W. An (2009)
Nucleic Acids Res. 37, 5993-6007
   Abstract »    Full Text »    PDF »
Cooperation between the INO80 Complex and Histone Chaperones Determines Adaptation of Stress Gene Transcription in the Yeast Saccharomyces cerevisiae.
E. Klopf, L. Paskova, C. Sole, G. Mas, A. Petryshyn, F. Posas, U. Wintersberger, G. Ammerer, and C. Schuller (2009)
Mol. Cell. Biol. 29, 4994-5007
   Abstract »    Full Text »    PDF »
Predicting nucleosome positions on the DNA: combining intrinsic sequence preferences and remodeler activities.
V. B. Teif and K. Rippe (2009)
Nucleic Acids Res. 37, 5641-5655
   Abstract »    Full Text »    PDF »
The XNP remodeler targets dynamic chromatin in Drosophila.
J. I. Schneiderman, A. Sakai, S. Goldstein, and K. Ahmad (2009)
PNAS 106, 14472-14477
   Abstract »    Full Text »    PDF »
BRG1 Increases Transcription of Proinflammatory Genes in Renal Ischemia.
M. Naito, R. A. Zager, and K. Bomsztyk (2009)
J. Am. Soc. Nephrol. 20, 1787-1796
   Abstract »    Full Text »    PDF »
The Beauty of Being a Variant: H2A.Z and the SWR1 Complex in Plants.
R. March-Diaz and J. C. Reyes (2009)
Mol Plant 2, 565-577
   Abstract »    Full Text »    PDF »
Histone H2A.Z is essential for estrogen receptor signaling.
N. Gevry, S. Hardy, P.-E. Jacques, L. Laflamme, A. Svotelis, F. Robert, and L. Gaudreau (2009)
Genes & Dev. 23, 1522-1533
   Abstract »    Full Text »    PDF »
Role of the Histone Variant H2A.Z/Htz1p in TBP Recruitment, Chromatin Dynamics, and Regulated Expression of Oleate-Responsive Genes.
Y. Wan, R. A. Saleem, A. V. Ratushny, O. Roda, J. J. Smith, C.-H. Lin, J.-H. Chiang, and J. D. Aitchison (2009)
Mol. Cell. Biol. 29, 2346-2358
   Abstract »    Full Text »    PDF »
Renal ischemia-reperfusion injury upregulates histone-modifying enzyme systems and alters histone expression at proinflammatory/profibrotic genes.
R. A. Zager and A. C. M. Johnson (2009)
Am J Physiol Renal Physiol 296, F1032-F1041
   Abstract »    Full Text »    PDF »
Dynamic Histone Variant Exchange Accompanies Gene Induction in T Cells.
E. L. Sutcliffe, I. A. Parish, Y. Q. He, T. Juelich, M. L. Tierney, D. Rangasamy, P. J. Milburn, C. R. Parish, D. J. Tremethick, and S. Rao (2009)
Mol. Cell. Biol. 29, 1972-1986
   Abstract »    Full Text »    PDF »
A Novel Proteomics Approach for the Discovery of Chromatin-associated Protein Networks.
J.-P. Lambert, L. Mitchell, A. Rudner, K. Baetz, and D. Figeys (2009)
Mol. Cell. Proteomics 8, 870-882
   Abstract »    Full Text »    PDF »
N Terminus of Swr1 Binds to Histone H2AZ and Provides a Platform for Subunit Assembly in the Chromatin Remodeling Complex.
W.-H. Wu, C.-H. Wu, A. Ladurner, G. Mizuguchi, D. Wei, H. Xiao, E. Luk, A. Ranjan, and C. Wu (2009)
J. Biol. Chem. 284, 6200-6207
   Abstract »    Full Text »    PDF »
A canonical promoter organization of the transcription machinery and its regulators in the Saccharomyces genome.
B. J. Venters and B. F. Pugh (2009)
Genome Res. 19, 360-371
   Abstract »    Full Text »    PDF »
Genome-wide analysis reveals a cell cycle-dependent mechanism controlling centromere propagation.
S. Erhardt, B. G. Mellone, C. M. Betts, W. Zhang, G. H. Karpen, and A. F. Straight (2008)
J. Cell Biol. 183, 805-818
   Abstract »    Full Text »    PDF »
Activation of facultatively silenced Drosophila loci associates with increased acetylation of histone H2AvD.
M. Tanabe, A. P. Kouzmenko, S. Ito, S. Sawatsubashi, E. Suzuki, S. Fujiyama, K. Yamagata, Y. Zhao, S. Kimura, T. Ueda, et al. (2008)
Genes Cells 13, 1279-1288
   Abstract »    Full Text »    PDF »
Loss of the Histone Variant H2A.Z Restores Capping to Checkpoint-Defective Telomeres in Drosophila.
Y. S. Rong (2008)
Genetics 180, 1869-1875
   Abstract »    Full Text »    PDF »
Genetic and Biochemical Analysis of Yeast and Human Cap Trimethylguanosine Synthase: FUNCTIONAL OVERLAP OF 2,2,7-TRIMETHYLGUANOSINE CAPS, SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENTS, PRE-mRNA SPLICING FACTORS, AND RNA DECAY PATHWAYS.
S. Hausmann, S. Zheng, M. Costanzo, R. L. Brost, D. Garcin, C. Boone, S. Shuman, and B. Schwer (2008)
J. Biol. Chem. 283, 31706-31718
   Abstract »    Full Text »    PDF »
Conservation and Rewiring of Functional Modules Revealed by an Epistasis Map in Fission Yeast.
A. Roguev, S. Bandyopadhyay, M. Zofall, K. Zhang, T. Fischer, S. R. Collins, H. Qu, M. Shales, H.-O. Park, J. Hayles, et al. (2008)
Science 322, 405-410
   Abstract »    Full Text »    PDF »
A comprehensive synthetic genetic interaction network governing yeast histone acetylation and deacetylation.
Y.-y. Lin, Y. Qi, J.-y. Lu, X. Pan, D. S. Yuan, Y. Zhao, J. S. Bader, and J. D. Boeke (2008)
Genes & Dev. 22, 2062-2074
   Abstract »    Full Text »    PDF »
Different Genetic Functions for the Rpd3(L) and Rpd3(S) Complexes Suggest Competition between NuA4 and Rpd3(S).
D. Biswas, S. Takahata, and D. J. Stillman (2008)
Mol. Cell. Biol. 28, 4445-4458
   Abstract »    Full Text »    PDF »
Human Rvb1/Tip49 Is Required for the Histone Acetyltransferase Activity of Tip60/NuA4 and for the Downregulation of Phosphorylation on H2AX after DNA Damage.
S. Jha, E. Shibata, and A. Dutta (2008)
Mol. Cell. Biol. 28, 2690-2700
   Abstract »    Full Text »    PDF »
Functional Dissection of the NuA4 Histone Acetyltransferase Reveals Its Role as a Genetic Hub and that Eaf1 Is Essential for Complex Integrity.
L. Mitchell, J.-P. Lambert, M. Gerdes, A. S. Al-Madhoun, I. S. Skerjanc, D. Figeys, and K. Baetz (2008)
Mol. Cell. Biol. 28, 2244-2256
   Abstract »    Full Text »    PDF »
Eaf1 Is the Platform for NuA4 Molecular Assembly That Evolutionarily Links Chromatin Acetylation to ATP-Dependent Exchange of Histone H2A Variants.
A. Auger, L. Galarneau, M. Altaf, A. Nourani, Y. Doyon, R. T. Utley, D. Cronier, S. Allard, and J. Cote (2008)
Mol. Cell. Biol. 28, 2257-2270
   Abstract »    Full Text »    PDF »
Nap1 Links Transcription Elongation, Chromatin Assembly, and Messenger RNP Complex Biogenesis.
B. C. Del Rosario and L. F. Pemberton (2008)
Mol. Cell. Biol. 28, 2113-2124
   Abstract »    Full Text »    PDF »
Global Analysis of Yeast Endosomal Transport Identifies the Vps55/68 Sorting Complex.
C. Schluter, K. K.Y. Lam, J. Brumm, B. W. Wu, M. Saunders, T. H. Stevens, J. Bryan, and E. Conibear (2008)
Mol. Biol. Cell 19, 1282-1294
   Abstract »    Full Text »    PDF »
Mutations in the Arabidopsis SWC6 gene, encoding a component of the SWR1 chromatin remodelling complex, accelerate flowering time and alter leaf and flower development.
A. Lazaro, A. Gomez-Zambrano, L. Lopez-Gonzalez, M. Pineiro, and J. A. Jarillo (2008)
J. Exp. Bot.
   Abstract »    Full Text »    PDF »
Molecular chaperone Hsp90 stabilizes Pih1/Nop17 to maintain R2TP complex activity that regulates snoRNA accumulation.
R. Zhao, Y. Kakihara, A. Gribun, J. Huen, G. Yang, M. Khanna, M. Costanzo, R. L. Brost, C. Boone, T. R. Hughes, et al. (2008)
J. Cell Biol. 180, 563-578
   Abstract »    Full Text »    PDF »
Probabilistic assembly of human protein interaction networks from label-free quantitative proteomics.
M. E. Sardiu, Y. Cai, J. Jin, S. K. Swanson, R. C. Conaway, J. W. Conaway, L. Florens, and M. P. Washburn (2008)
PNAS 105, 1454-1459
   Abstract »    Full Text »    PDF »
Msc1 Acts Through Histone H2A.Z to Promote Chromosome Stability in Schizosaccharomyces pombe.
S. Ahmed, B. Dul, X. Qiu, and N. C. Walworth (2007)
Genetics 177, 1487-1497
   Abstract »    Full Text »    PDF »
DNA Damage-Dependent Acetylation and Ubiquitination of H2AX Enhances Chromatin Dynamics.
T. Ikura, S. Tashiro, A. Kakino, H. Shima, N. Jacob, R. Amunugama, K. Yoder, S. Izumi, I. Kuraoka, K. Tanaka, et al. (2007)
Mol. Cell. Biol. 27, 7028-7040
   Abstract »    Full Text »    PDF »
Mining biological networks for unknown pathways.
A. Cakmak and G. Ozsoyoglu (2007)
Bioinformatics 23, 2775-2783
   Abstract »    Full Text »    PDF »
Genetic Suppressors of Caenorhabditis elegans pha-4/FoxA Identify the Predicted AAA Helicase ruvb-1/RuvB.
D. L. Updike and S. E. Mango (2007)
Genetics 177, 819-833
   Abstract »    Full Text »    PDF »
The first bromodomain of Brdt, a testis-specific member of the BET sub-family of double-bromodomain-containing proteins, is essential for male germ cell differentiation.
E. Shang, H. D. Nickerson, D. Wen, X. Wang, and D. J. Wolgemuth (2007)
Development 134, 3507-3515
   Abstract »    Full Text »    PDF »
Redundancy of Chromatin Remodeling Pathways for the Induction of the Yeast PHO5 Promoter in Vivo.
S. Barbaric, T. Luckenbach, A. Schmid, D. Blaschke, W. Horz, and P. Korber (2007)
J. Biol. Chem. 282, 27610-27621
   Abstract »    Full Text »    PDF »
Centromere identity is specified by a single centromeric nucleosome in budding yeast.
S. Furuyama and S. Biggins (2007)
PNAS 104, 14706-14711
   Abstract »    Full Text »    PDF »
The Chromatin Remodeling Protein, SRCAP, Is Critical for Deposition of the Histone Variant H2A.Z at Promoters.
M. M. Wong, L. K. Cox, and J. C. Chrivia (2007)
J. Biol. Chem. 282, 26132-26139
   Abstract »    Full Text »    PDF »
Regulation of Telomere Structure and Functions by Subunits of the INO80 Chromatin Remodeling Complex.
E. Y. Yu, O. Steinberg-Neifach, A. T. Dandjinou, F. Kang, A. J. Morrison, X. Shen, and N. F. Lue (2007)
Mol. Cell. Biol. 27, 5639-5649
   Abstract »    Full Text »    PDF »
NuA4-Directed Chromatin Transactions throughout the Saccharomyces cerevisiae Genome.
M. Durant and B. F. Pugh (2007)
Mol. Cell. Biol. 27, 5327-5335
   Abstract »    Full Text »    PDF »
p21 transcription is regulated by differential localization of histone H2A.Z.
N. Gevry, H. M. Chan, L. Laflamme, D. M. Livingston, and L. Gaudreau (2007)
Genes & Dev. 21, 1869-1881
   Abstract »    Full Text »    PDF »
The Saccharomyces cerevisiae Histone Demethylase Jhd1 Fine-Tunes the Distribution of H3K36me2.
J. Fang, G. J. Hogan, G. Liang, J. D. Lieb, and Y. Zhang (2007)
Mol. Cell. Biol. 27, 5055-5065
   Abstract »    Full Text »    PDF »
Nucleosome stability mediated by histone variants H3.3 and H2A.Z.
C. Jin and G. Felsenfeld (2007)
Genes & Dev. 21, 1519-1529
   Abstract »    Full Text »    PDF »
Demethylation of Histone H3K36 and H3K9 by Rph1: a Vestige of an H3K9 Methylation System in Saccharomyces cerevisiae?.
R. J. Klose, K. E. Gardner, G. Liang, H. Erdjument-Bromage, P. Tempst, and Y. Zhang (2007)
Mol. Cell. Biol. 27, 3951-3961
   Abstract »    Full Text »    PDF »
The Tup1 Corepressor Directs Htz1 Deposition at a Specific Promoter Nucleosome Marking the GAL1 Gene for Rapid Activation.
T. Gligoris, G. Thireos, and D. Tzamarias (2007)
Mol. Cell. Biol. 27, 4198-4205
   Abstract »    Full Text »    PDF »
A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression.
J. Lu, M.-L. Ruhf, N. Perrimon, and P. Leder (2007)
PNAS 104, 9381-9386
   Abstract »    Full Text »    PDF »
The Nucleosome Assembly Activity of NAP1 Is Enhanced by Alien.
M. Eckey, W. Hong, M. Papaioannou, and A. Baniahmad (2007)
Mol. Cell. Biol. 27, 3557-3568
   Abstract »    Full Text »    PDF »
Arabidopsis homologs of components of the SWR1 complex regulate flowering and plant development.
K. Choi, C. Park, J. Lee, M. Oh, B. Noh, and I. Lee (2007)
Development 134, 1931-1941
   Abstract »    Full Text »    PDF »
Actin-related protein Arp4 functions in kinetochore assembly.
H. Ogiwara, A. Ui, S. Kawashima, K. Kugou, F. Onoda, H. Iwahashi, M. Harata, K. Ohta, T. Enomoto, and M. Seki (2007)
Nucleic Acids Res. 35, 3109-3117
   Abstract »    Full Text »    PDF »
Critical role of the p400/mDomino chromatin-remodeling ATPase in embryonic hematopoiesis.
T. Ueda, R. Watanabe-Fukunaga, H. Ogawa, H. Fukuyama, Y. Higashi, S. Nagata, and R. Fukunaga (2007)
Genes Cells 12, 581-592
   Abstract »    Full Text »    PDF »
Nap1: taking a closer look at a juggler protein of extraordinary skills.
J. Zlatanova, C. Seebart, and M. Tomschik (2007)
FASEB J 21, 1294-1310
   Abstract »    Full Text »    PDF »
The Nuclear Actin-related Protein of Saccharomyces cerevisiae, Arp4, Directly Interacts with the Histone Acetyltransferase Esa1p.
F. Steinboeck, A. Bogusch, A. Kaufmann, and E. Heidenreich (2007)
J. Biochem. 141, 661-668
   Abstract »    Full Text »    PDF »
Dependency of ISW1a Chromatin Remodeling on Extranucleosomal DNA.
V. K. Gangaraju and B. Bartholomew (2007)
Mol. Cell. Biol. 27, 3217-3225
   Abstract »    Full Text »    PDF »
Ubiquitylation of histone H2B controls RNA polymerase II transcription elongation independently of histone H3 methylation.
J. C. Tanny, H. Erdjument-Bromage, P. Tempst, and C. D. Allis (2007)
Genes & Dev. 21, 835-847
   Abstract »    Full Text »    PDF »
Toward a Comprehensive Atlas of the Physical Interactome of Saccharomyces cerevisiae.
S. R. Collins, P. Kemmeren, X.-C. Zhao, J. F. Greenblatt, F. Spencer, F. C. P. Holstege, J. S. Weissman, and N. J. Krogan (2007)
Mol. Cell. Proteomics 6, 439-450
   Abstract »    Full Text »    PDF »
SEF, a New Protein Required for Flowering Repression in Arabidopsis, Interacts with PIE1 and ARP6.
R. March-Diaz, M. Garcia-Dominguez, F. J. Florencio, and J. C. Reyes (2007)
Plant Physiology 143, 893-901
   Abstract »    Full Text »    PDF »
Repression of Flowering in Arabidopsis Requires Activation of FLOWERING LOCUS C Expression by the Histone Variant H2A.Z.
R. B. Deal, C. N. Topp, E. C. McKinney, and R. B. Meagher (2007)
PLANT CELL 19, 74-83
   Abstract »    Full Text »    PDF »
Using genomics and proteomics to investigate mechanisms of transcriptional silencing in Saccharomyces cerevisiae.
L. Gao and D. S. Gross (2006)
Brief Funct Genomic Proteomic 5, 280-288
   Abstract »    Full Text »    PDF »
A novel histone exchange factor, protein phosphatase 2C{gamma}, mediates the exchange and dephosphorylation of H2A-H2B.
H. Kimura, N. Takizawa, E. Allemand, T. Hori, F. J. Iborra, N. Nozaki, M. Muraki, M. Hagiwara, A. R. Krainer, T. Fukagawa, et al. (2006)
J. Cell Biol. 175, 389-400
   Abstract »    Full Text »    PDF »
Regulation of ISW2 by Concerted Action of Histone H4 Tail and Extranucleosomal DNA..
W. Dang, M. N. Kagalwala, and B. Bartholomew (2006)
Mol. Cell. Biol. 26, 7388-7396
   Abstract »    Full Text »    PDF »
SAS-mediated acetylation of histone H4 Lys 16 is required for H2A.Z incorporation at subtelomeric regions in Saccharomyces cerevisiae.
W.-J. Shia, B. Li, and J. L. Workman (2006)
Genes & Dev. 20, 2507-2512
   Abstract »    Full Text »    PDF »
Yeast G1 DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodeling.
A. Javaheri, R. Wysocki, O. Jobin-Robitaille, M. Altaf, J. Cote, and S. J. Kron (2006)
PNAS 103, 13771-13776
   Abstract »    Full Text »    PDF »
Snf2 family ATPases and DExx box helicases: differences and unifying concepts from high-resolution crystal structures.
H. Durr, A. Flaus, T. Owen-Hughes, and K.-P. Hopfner (2006)
Nucleic Acids Res. 34, 4160-4167
   Abstract »    Full Text »    PDF »
Rad54: the Swiss Army knife of homologous recombination?.
W.-D. Heyer, X. Li, M. Rolfsmeier, and X.-P. Zhang (2006)
Nucleic Acids Res. 34, 4115-4125
   Abstract »    Full Text »    PDF »
Dynamic Regulation of Histone Modifications in Xenopus Oocytes through Histone Exchange..
M. D. Stewart, J. Sommerville, and J. Wong (2006)
Mol. Cell. Biol. 26, 6890-6901
   Abstract »    Full Text »    PDF »
Histone variants--the structure behind the function.
J. Ausio (2006)
Brief Funct Genomic Proteomic 5, 228-243
   Abstract »    Full Text »    PDF »
Drosophila Reptin and Other TIP60 Complex Components Promote Generation of Silent Chromatin.
D. Qi, H. Jin, T. Lilja, and M. Mannervik (2006)
Genetics 174, 241-251
   Abstract »    Full Text »    PDF »
Isw1 Functions in Parallel with the NuA4 and Swr1 Complexes in Stress-Induced Gene Repression..
K. C. Lindstrom, J. C. Vary Jr., M. R. Parthun, J. Delrow, and T. Tsukiyama (2006)
Mol. Cell. Biol. 26, 6117-6129
   Abstract »    Full Text »    PDF »
Analysis of Human Histone H2AZ Deposition In Vivo Argues against Its Direct Role in Epigenetic Templating Mechanisms..
A. Viens, U. Mechold, F. Brouillard, C. Gilbert, P. Leclerc, and V. Ogryzko (2006)
Mol. Cell. Biol. 26, 5325-5335
   Abstract »    Full Text »    PDF »
The X and Y Chromosomes Assemble into H2A.Z, Containing Facultative Heterochromatin, following Meiosis..
I. K. Greaves, D. Rangasamy, M. Devoy, J. A. Marshall Graves, and D. J. Tremethick (2006)
Mol. Cell. Biol. 26, 5394-5405
   Abstract »    Full Text »    PDF »
Constitutive Expression Exposes Functional Redundancy between the Arabidopsis Histone H2A Gene HTA1 and Other H2A Gene Family Members.
H. Yi, N. Sardesai, T. Fujinuma, C.-W. Chan, Veena, and S. B. Gelvin (2006)
PLANT CELL 18, 1575-1589
   Abstract »    Full Text »    PDF »
On the Mechanism of Nucleosome Assembly by Histone Chaperone NAP1.
J. Mazurkiewicz, J. F. Kepert, and K. Rippe (2006)
J. Biol. Chem. 281, 16462-16472
   Abstract »    Full Text »    PDF »
Analysis of Nucleosome Repositioning by Yeast ISWI and Chd1 Chromatin Remodeling Complexes.
C. Stockdale, A. Flaus, H. Ferreira, and T. Owen-Hughes (2006)
J. Biol. Chem. 281, 16279-16288
   Abstract »    Full Text »    PDF »
macroH2A1 Histone Variants Are Depleted on Active Genes but Concentrated on the Inactive X Chromosome.
L. N. Changolkar and J. R. Pehrson (2006)
Mol. Cell. Biol. 26, 4410-4420
   Abstract »    Full Text »    PDF »
Identification of multiple distinct Snf2 subfamilies with conserved structural motifs.
A. Flaus, D. M. A. Martin, G. J. Barton, and T. Owen-Hughes (2006)
Nucleic Acids Res. 34, 2887-2905
   Abstract »    Full Text »    PDF »
Inaugural Article: Histone H3 variants and their potential role in indexing mammalian genomes: The "H3 barcode hypothesis".
S. B. Hake and C. D. Allis (2006)
PNAS 103, 6428-6435
   Abstract »    Full Text »    PDF »
Novel Regulatory Properties of Saccharomyces cerevisiae Arp4..
F. Steinboeck, L. Krupanska, A. Bogusch, A. Kaufmann, and E. Heidenreich (2006)
J. Biochem. 139, 741-751
   Abstract »    Full Text »    PDF »
EARLY IN SHORT DAYS 1 (ESD1) encodes ACTIN-RELATED PROTEIN 6 (AtARP6), a putative component of chromatin remodelling complexes that positively regulates FLC accumulation in Arabidopsis.
M. Martin-Trillo, A. Lazaro, R. S. Poethig, C. Gomez-Mena, M. A. Pineiro, J. M. Martinez-Zapater, and J. A. Jarillo (2006)
Development 133, 1241-1252
   Abstract »    Full Text »    PDF »
Distinct Roles for the Essential MYST Family HAT Esa1p in Transcriptional Silencing.
A. S. Clarke, E. Samal, and L. Pillus (2006)
Mol. Biol. Cell 17, 1744-1757
   Abstract »    Full Text »    PDF »
The Saccharomyces cerevisiae histone H2A variant Htz1 is acetylated by NuA4..
M.-C. Keogh, T. A. Mennella, C. Sawa, S. Berthelet, N. J. Krogan, A. Wolek, V. Podolny, L. R. Carpenter, J. F. Greenblatt, K. Baetz, et al. (2006)
Genes & Dev. 20, 660-665
   Abstract »    Full Text »    PDF »
Telomeric heterochromatin boundaries require NuA4-dependent acetylation of histone variant H2A.Z in Saccharomy cescerevisiae..
J. E. Babiarz, J. E. Halley, and J. Rine (2006)
Genes & Dev. 20, 700-710
   Abstract »    Full Text »    PDF »
Acetylation of H2AZ Lys 14 is associated with genome-wide gene activity in yeast..
C. B. Millar, F. Xu, K. Zhang, and M. Grunstein (2006)
Genes & Dev. 20, 711-722
   Abstract »    Full Text »    PDF »
The Histone Chaperone Asf1 Increases the Rate of Histone Eviction at the Yeast PHO5 and PHO8 Promoters.
P. Korber, S. Barbaric, T. Luckenbach, A. Schmid, U. J. Schermer, D. Blaschke, and W. Horz (2006)
J. Biol. Chem. 281, 5539-5545
   Abstract »    Full Text »    PDF »
Mechanism of Polymerase II Transcription Repression by the Histone Variant macroH2A.
C.-M. Doyen, W. An, D. Angelov, V. Bondarenko, F. Mietton, V. M. Studitsky, A. Hamiche, R. G. Roeder, P. Bouvet, and S. Dimitrov (2006)
Mol. Cell. Biol. 26, 1156-1164
   Abstract »    Full Text »    PDF »
The structure of nucleosome assembly protein 1.
Y.-J. Park and K. Luger (2006)
PNAS 103, 1248-1253
   Abstract »    Full Text »    PDF »
H2A.Z Functions To Regulate Progression through the Cell Cycle.
N. Dhillon, M. Oki, S. J. Szyjka, O. M. Aparicio, and R. T. Kamakaka (2006)
Mol. Cell. Biol. 26, 489-501
   Abstract »    Full Text »    PDF »
Heads and tails: 30 million years of the Afar plume.
T. Furman, J. Bryce, T. Rooney, B. Hanan, G. Yirgu, and D. Ayalew (2006)
Geological Society, London, Special Publications 259, 95-119
   Abstract »    PDF »
Changes in Attitude, Changes in Latitude: Nuclear Receptors Remodeling Chromatin to Regulate Transcription.
J. Chen, H. K. Kinyamu, and T. K. Archer (2006)
Mol. Endocrinol. 20, 1-13
   Abstract »    Full Text »    PDF »
Preferential occupancy of histone variant H2AZ at inactive promoters influences local histone modifications and chromatin remodeling.
B. Li, S. G. Pattenden, D. Lee, J. Gutierrez, J. Chen, C. Seidel, J. Gerton, and J. L. Workman (2005)
PNAS 102, 18385-18390
   Abstract »    Full Text »    PDF »
The mobile nucleoporin Nup2p and chromatin-bound Prp20p function in endogenous NPC-mediated transcriptional control.
D. J. Dilworth, A. J. Tackett, R. S. Rogers, E. C. Yi, R. H. Christmas, J. J. Smith, A. F. Siegel, B. T. Chait, R. W. Wozniak, and J. D. Aitchison (2005)
J. Cell Biol. 171, 955-965
   Abstract »    Full Text »    PDF »
A Mammalian Chromatin Remodeling Complex with Similarities to the Yeast INO80 Complex.
J. Jin, Y. Cai, T. Yao, A. J. Gottschalk, L. Florens, S. K. Swanson, J. L. Gutierrez, M. K. Coleman, J. L. Workman, A. Mushegian, et al. (2005)
J. Biol. Chem. 280, 41207-41212
   Abstract »    Full Text »    PDF »
Dynamic regulation of replication independent deposition of histone H3 in fission yeast.
E. S. Choi, J. A Shin, H. S. Kim, and Y. K. Jang (2005)
Nucleic Acids Res. 33, 7102-7110
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)