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Published Online September 4, 2003
Science DOI: 10.1126/science.1087139

Reports

Submitted on May 22, 2003
Accepted on August 26, 2003

Isolation and Characterization of Viruses Related to the SARS Coronavirus from Animals in Southern China

Y. Guan 1*, B. J. Zheng 1, Y. Q. He 2, X. L. Liu 2, Z. X. Zhuang 2, C. L. Cheung 1, S. W. Luo 1, P. H. Li 1, L. J. Zhang 1, Y. J. Guan 1, K. M. Butt 1, K. L. Wong 1, K. W. Chan 3, W. Lim 4, K. F. Shortridge 1, K. Y. Yuen 1, J. S. M. Peiris 1, L. L. M. Poon 1

1 Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong SAR, P.R. China.
2 Center for Disease Control and Prevention, Shenzhen, Guangdong Province, P.R. China.
3 Department of Pathology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong SAR, P.R. China.
4 Government Virus Unit, Department of Health, Hong Kong SAR, P.R. China.

* To whom correspondence should be addressed. E-mail: yguan{at}hkucc.hku.hk.

A novel coronavirus (SCoV) is the etiological agent of the Severe Acute Respiratory Syndrome. SCoV-like viruses were isolated from Himalayan palm civets found in a live animal market in Guangdong, China. Evidence of virus infection was also detected in other animal, including a raccoon-dog, and in humans working at the same market. All the animal isolates retain a 29-nucleotide sequence, which is not found in most human isolates. The detection of SCoV-like viruses in small wild mammals in live retail market indicates a route of interspecies transmission, although the natural reservoir is not known.


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   Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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Isolation of avian infectious bronchitis coronavirus from domestic peafowl (Pavo cristatus) and teal (Anas).
S. Liu, J. Chen, J. Chen, X. Kong, Y. Shao, Z. Han, L. Feng, X. Cai, S. Gu, and M. Liu (2005)
J. Gen. Virol. 86, 719-725
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Use of the COOH Portion of the Nucleocapsid Protein in an Antigen-Capturing Enzyme-Linked Immunosorbent Assay for Specific and Sensitive Detection of Severe Acute Respiratory Syndrome Coronavirus.
M. Qiu, J. Wang, H. Wang, Z. Chen, E. Dai, Z. Guo, X. Wang, X. Pang, B. Fan, J. Wen, et al. (2005)
Clin. Vaccine Immunol. 12, 474-476
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Recombinant Modified Vaccinia Virus Ankara Expressing the Spike Glycoprotein of Severe Acute Respiratory Syndrome Coronavirus Induces Protective Neutralizing Antibodies Primarily Targeting the Receptor Binding Region.
Z. Chen, L. Zhang, C. Qin, L. Ba, C. E. Yi, F. Zhang, Q. Wei, T. He, W. Yu, J. Yu, et al. (2005)
J. Virol. 79, 2678-2688
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Development of a quantitative assay for SARS coronavirus and correlation of GAPDH mRNA with SARS coronavirus in clinical specimens.
S C C Wong, J K C Chan, K C Lee, E S F Lo, and D N C Tsang (2005)
J. Clin. Pathol. 58, 276-280
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Identification of a Novel Coronavirus in Bats.
L. L. M. Poon, D. K. W. Chu, K. H. Chan, O. K. Wong, T. M. Ellis, Y. H. C. Leung, S. K. P. Lau, P. C. Y. Woo, K. Y. Suen, K. Y. Yuen, et al. (2005)
J. Virol. 79, 2001-2009
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