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Submitted on May 10, 2002
Accepted on September 3, 2002
A Stem Cell Molecular Signature
Natalia B. Ivanova 1,John T. Dimos 1,Christoph Schaniel 1,Jason A. Hackney 1,Kateri A. Moore 1,Ihor R. Lemischka 1*
1 Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
* To whom correspondence should be addressed. E-mail: ilemischka{at}molbio.princeton.edu.
Mechanisms regulating self-renewal and cell fate decisions in mammalian stem cells are poorly understood. We determined global gene expression profiles for mouse and human hematopoietic stem cells and other stages of the hematopoietic hierarchy. Murine and human hematopoietic stem cells share a number of expressed gene products, defining key conserved regulatory pathways in this developmental system. Moreover, in the mouse a portion of the genetic program of hematopoietic stem cells is shared with embryonic and neural stem cells. This overlapping set of gene products represents a molecular signature of stem cells.
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M. Podesta, F. Benvenuto, A. Pitto, O. Figari, A. Bacigalupo, S. Bruzzone, L. Guida, L. Franco, L. Paleari, N. Bodrato, et al. (2005)
J. Biol. Chem.
280, 5343-5349
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Ephrin-A2 reverse signaling negatively regulates neural progenitor proliferation and neurogenesis.
J. Holmberg, A. Armulik, K.-A. Senti, K. Edoff, K. Spalding, S. Momma, R. Cassidy, J. G. Flanagan, and J. Frisen (2005)
Genes & Dev.
19, 462-471
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Gene expression profile of murine long-term reconstituting vs. short-term reconstituting hematopoietic stem cells.
J. F. Zhong, Y. Zhao, S. Sutton, A. Su, Y. Zhan, L. Zhu, C. Yan, T. Gallaher, P. B. Johnston, W. F. Anderson, et al. (2005)
PNAS
102, 2448-2453
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A STAT5 modifier locus on murine chromosome 7 modulates engraftment of hematopoietic stem cells during steady-state hematopoiesis.
Soluble factors elaborated by human brain endothelial cells induce the concomitant expansion of purified human BM CD34+CD38- cells and SCID-repopulating cells.
J. P. Chute, G. G. Muramoto, J. Fung, and C. Oxford (2005)
Blood
105, 576-583
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